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Appaloosa Horse Club Approves EQUIOXX®, ULCERGARD®, GASTROGARD®

DULUTH, GA — Nov. 12, 2008 — Starting Jan. 1, 2009, Appaloosa Horse Club (ApHC) members will be able to use EQUIOXX® (firocoxib), ULCERGARD® (omeprazole) or GASTROGARD® (omeprazole) prior to competition.1

The decision by the ApHC Board of Directors provides thousands of horse owners nationwide with FDA-approved options for common diseases like equine osteoarthritis and stomach ulcers.1

“I believe these products are great options to help us maintain the health of our equine partners,” says Frank Larrabee, president of the ApHC Board of Directors. “Personally, my own horses have experienced stomach ulcers and the need for NSAIDs, and I’m sure the thousands of Appaloosa members involved in equine activities are faced with the same concerns. We salute the efforts of the researchers who have helped make life a little easier on these horses.”

With the approval, EQUIOXX is the only nonsteroidal anti-inflammatory drug (NSAID) approved for use up to 14 consecutive days in the ApHC.1 EQUIOXX also is approved for use in the American Quarter Horse Association2 and United States Equestrian Federation.3

EQUIOXX is the first equine oral NSAID to be approved in more than 20 years. It is proven to control joint pain and inflammation associated with equine osteoarthritis, which is one of the most common causes of lameness in horses. Also known as degenerative joint disease, osteoarthritis can develop in horses as young as 2 years old.4 EQUIOXX works quickly to provide 24 hours of pain relief and is easily administered as an oral paste.5

The ApHC also approved GASTROGARD and ULCERGARD for use no more than 24 hours prior to competition.1 GASTROGARD and ULCERGARD are the first and only FDA-approved products for the treatment and prevention of equine stomach ulcers, respectively.

Horses can develop stomach ulcers in as little as five days,6 but GASTROGARD can treat stomach ulcers even while horses continue to train. Proactive use of ULCERGARD during short or long periods of time* can help reduce the risk of stomach ulcers in horses that regularly deal with stressful situations, such as training, traveling and competing.7

“Equine osteoarthritis and stomach ulcers are common for horses of all breeds,” says Dr. Frank Hurtig, director, Veterinary Services, Merial. “Now, competitors in ApHC events can help ensure their horses have FDA-approved choices to help them address these diseases and enable their horses to compete at their best.”

For complete ApHC rules regarding the use of EQUIOXX, GASTROGARD and ULCERGARD, please visit http://www.appaloosa.com.

Merial is a world-leading, innovation-driven animal health company, providing a comprehensive range of products to enhance the health, well-being and performance of a wide range of animals. Merial employs approximately 5,000 people and operates in more than 150 countries worldwide. Its 2007 sales were nearly $2.5 billion. Merial Limited is a joint venture between Merck & Co., Inc. and sanofi-aventis. For more information, please see http://www.merial.com.

As with any prescription medication, prior to use, a veterinarian should perform a physical examination and review the horse’s medical history. A veterinarian should advise horse owners to observe for signs of potential drug toxicity. As a class, nonsteroidal anti-inflammatory drugs may be associated with gastrointestinal and renal toxicity. Use with other NSAIDs, corticosteroids or nephrotoxic medication should be avoided. EQUIOXX has not been tested in horses less than 1 year of age or in breeding horses, or pregnant or lactating mares. For additional information please refer to the prescribing information or visit http://www.equioxx.com.

Federal (USA) law restricts GASTROGARD to use by or on the order of a licensed veterinarian. GASTROGARD is indicated for the treatment and prevention of recurrence of gastric ulcers in horses and foals 4 weeks and older. In an efficacy trial, no adverse reactions were observed. Safety in pregnant or lactating mares has not been determined. For more information, visit http://www.gastrogard.com.

ULCERGARD can be used in horses that weigh at least 600 pounds. The effectiveness of ULCERGARD in the prevention of gastric ulcers in foals and weanlings has not been evaluated. ULCERGARD may be used safely in breeding stallions. Safety in pregnant mares has not been determined.

*When treated for 8 or 28 days, ULCERGARD is proven to effectively prevent stomach ulcers in horses exposed to stressful conditions.

®EQUIOXX is a registered trademark of Merial. ®GASTROGARD and ULCERGARD are registered trademarks of the AstraZeneca Group of Companies. ©2008 Merial Limited. Duluth, GA. All rights reserved. LAGEEQX872 (11/08)

EQUIOXX Prescription Information

GASTROGARD Prescription Information

1. Appaloosa Horse Club Board of Directors unapproved summary of motions. July 6, 2008. Available at: http://www.appaloosa.com/pdfs/SummaryofMotions07_06_08.pdf. Accessed August 20, 2008.

2. American Quarter Horse Association. Show rules and regulations. Official Handbook of Rules and Regulations. 2008:128. Available at: http://www.aqha.com/association/registration/pdf/showrules_08.pdf. Accessed February 1, 2008.

3. United States Equestrian Federation. Drugs and Medications Guidelines. 2007:2-3. Available at:

http://www.usef.org/documents/competitions/2007/2007DrugsMedsGuidelines.pdf. Accessed February 13, 2008.

4. Schlueter AE and Orth MW. Equine osteoarthritis: a brief review of the disease and its causes. Equine and Comparative Exercise Physiology 2004;1(4):221–231.

5. EQUIOXX Freedom of information summary.

6. McClure SR, Carithers DS, Gross SJ, Murray MJ. Gastric ulcer development in horses in a simulated show or training environment. J Am Vet Med Assoc 2005;227(5):775-777.

7. ULCERGARD product label.


3239 Satellite Blvd.

Duluth, GA 30096



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